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Twenty years after the discovery of neural stem cells, the question whether the central nervous system can be considered among regenerative tissues is still open. On one side, deep characterization of neural stem and progenitor cells, their niches, and their progeny in brain neurogenic sites overtly showed that new neurons can be generated in the brain of adult mammals, including humans. On the other side, many problems arise when stem cells encounter the mature brain parenchyma, still hampering the development of efficacious therapeutic approaches with endogenous or exogenously-delivered neural stem cells. This book tries to make the point on these extremely promising, yet unresolved, issues.

Proteins. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cellular biology (cytology)

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Cytology. --- Biología celular. --- Citología. --- Cell biology --- Cellular biology --- Biology --- Cells

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The aim of this book is to present review articles describing the latest theoretical and experimental developments in the field of cold atoms and molecules. Our hope is that this series will promote research by both highlighting recent breakthroughs and by outlining some of the most promising research directions in the field.

Molecular biology. --- Cytogenetics. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytology --- Genetics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology

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Stem cells have generated a lot of excitement among the researchers, clinicians and the public alike. Various types of stem cells are being evaluated for their regenerative potential. Marginal benefit resulting by transplanting autologus stem cells (deemed to be absolutely safe) in various clinical conditions has been proposed to be a growth factor effect rather than true regeneration. In contrast, various pre-clinical studies have been undertaken, using differentiated cells from embryonic stem cells or induced pluripotent stem cells have shown promise, functional improvement and no signs of teratoma formation. The scientists are not in a rush to reach the clinic but a handful of clinical studies have shown promise. This book is a collection of studies/reviews, beginning with an introduction to the pluripotent stem cells and covering various aspects like derivation, differentiation, ethics, etc., and hence would provide insight into the recent standing on the pluripotent stem cells biology. The chapters have been categorized into three sections, covering subjects ranging from the generation of pluripotent stem cells and various means of their derivation from embryonic as well as adult tissues, the mechanistic understanding of pluripotency and narrating the potential therapeutic implications of these in vitro generated cells in various diseases, in addition to the associated pros and cons in the same.

Proteins. --- Bioethics. --- Stem cells --- Transplantation. --- Stem cell transplantation --- Cell transplantation --- Biology --- Biomedical ethics --- Life sciences --- Life sciences ethics --- Science --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Moral and ethical aspects --- Cellular biology (cytology)

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Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).

Stem cell biology and regenerative medicine. --- Diseases. --- Human beings --- Illness --- Illnesses --- Morbidity --- Sickness --- Sicknesses --- Medicine --- Epidemiology --- Health --- Pathology --- Sick --- Diseases --- Stem cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Cellular biology (cytology)